Misa Amane the antihero thought that she had Light Yagami's love at stake, and she was nothing to lose.
Ryota knows how to gamble, but his track record isn't the best, such as when he lost to Mary early on.
Ragdoll lost her useful Quirk, her pro hero status, and even her hero costume, meaning she has little left to fight for.
Naofumi wandered alone, desperately trying to grind XP while being a defense-only hero practically incapable of killing monsters.
After a point in the story, the pink-haired Hina Sato, calling herself Odin, had something to lose.
It's true that even when Thorfinn Karselfni the Viking lost his beloved father Thors, he still had a caring mother.
It's true that the female gunslinger Revy has a small crew to call her own, but she wouldn't exactly break down in tears.
Kenshiro the shonen hero may have inspired the design of both Guts and Jonathan Joestar, with Kenshiro.
The caped baldy superhero, Saitama, has little to lose except his reputation as a hero who's rising in the ranks.
During certain story arcs, the mighty seinen swordsman Guts did have something to lose, such as his fellow Band.